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Catalogue of Somatic
Mutations in Cancer (COSMIC)

Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource, COSMIC.

What is the impact?

Ever imagine what the impact of misidentifying the correct mutation could be on cancer or missing critical information in your research? What would be the impact to a child fighting with cancer or a loved one not getting the right treatment at the right time? What would the impact of missing an already identified variant be on your research? These questions are best left unanswered by choosing to work with only the best and most comprehensive database for human cancer mutations.

With over 71 million somatic mutations, COSMIC is the world’s largest expert-curated somatic mutation database. Trusted by over >20.000 users, it is integral to any clinical assessment of somatic variants. Integrating COSMIC into your NGS pipeline accelerates cancer sample analysis by rapidly prioritizing cancer driver mutations, distinguishing VUSes, and determining if an alteration is common or rare in the cancer type of interest.

Discover the impact of mutations in Human Cancers

Empower your research and diagnosis with the world’s largest database of human cancer mutations

with well over 20,000 users and in excess of 10,000 citations


curated mutations reports

All data has been manually curated, standardized and evaluated for accuracy from peer-reviewed papers by a team of postdoctoral scientists.


human samples studied

COSMIC provides genome wide annotation with over 37 million coding mutations plus substantial coverage of  all other oncogenic non-coding regions.


peer-reviewed papers

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

View the complete COSMIC database statistics here.

See what’s new in the latest COSMIC release (v92) here.

COSMIC is constantly being updated with the latest information on cancer mutations. With over 5,000,000 coding mutations added in 2019 to 2020, almost double the coding mutations that have been collected over the past 15 years.

Created with Highcharts 8.2.2YearNumber of coding mutationsCoding mutations added to COSMIC every year20102012201420162018202002.5M5M7.5M10M12.5M15MNovember 2017 coding mutations: 5 366 273
                                                         Click here to watch more tutorials
COSMIC: Describing millions of somatic mutations at high resolution across every form of cancer underpins precision oncology research.

Attend this insightful webinar if you want to know all about COSMIC and its hand curated content, Actionability – it’s latest offering on drugs that target specific somatic mutations and much more!



The fifth release of Actionability, the newest product in the COSMIC suite, is now available. Actionability is a vital tool for anyone working in precision oncology, offering expert-curated information on the availability and development of drugs targeting somatic mutations in cancer, as well as case studies, clinical trials, and regulatory body data critical to improving precision oncology decision-making.

QIAGEN is delighted to offer the COSMIC Database from the Sanger Wellcome Institute. COSMIC joins QIAGEN's comprehensive portfolio of somatic interpretation solutions.

Jonathan Sheldon, PhD

Senior Vice President, QIAGEN Digital Insightsa

Making a difference in the cancer landscape

COSMIC has been fueling cancer research for the past 15 years. From its humble beginnings see how this knowledge base plays its part in the fight against cancer and making a difference in patient care.

Interested in knowing more?

Speak to a QIAGEN subject matter expert

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